Nano Drug to take on Osteoporosis

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  • In a novel development, a team of engineers and pharmacologists from the Indian Institute of Science (IISc) and Al-Ameen College of Pharmacy has come up with nano particles that can stimulate growth of boneforming cells and deliver the drug used for                     osteoporosis.
  • Quoting various studies, the team pointed out that at least nine million bone fractures occur annually due to osteoporosis, a                   progressive bone disease in which the bone loses both its mass and density .
  • Current treatment regimes involve restricting further bone damage, but not restoring previous strength.
  • Zoledronic acid (ZOL) is the commonly used drug.
  • It has successfully reduced risk of fracture in postmenopausal women.
  • Its prolonged use can cause several adverse effects like unwanted bone changes.
  • The team has now come up with a modified ZOL drug, proven effective in treatment of postmenopausal osteoporosis.
  • These are made of synthetic hydroxyapatite (HA).
  • HA is naturally present in our bodies: it makes up bone mineral and the matrix of teeth and stimulates bone-forming cells.
  • Deepak Kumar Khajuria, lead author of the team said: We've designed a new formulation, where the ZOL is first adsorbed on nano         particles of hydroxyapatite and carried to osteoporotic bone by intravenous injection.
  • The team has been able to demonstrate successfully that this formulation not only prevents further bone loss, but also stimulates         bone growth.
  • The team tested it on female rat
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